Dendritic Cell Development
Dendritic cells are an essential link between the innate and adaptive arms of the immune system. The dendritic cell development project focuses on the progression of the stem and progenitor cells found in bone marrow into inflammatory dendritic cells along the myeloid developmental pathway. Discrete stages along this development are notoriously hard to isolate-- the Schwartz laboratory focuses on methods for generating large numbers of such progenitor stages and determining their functions. This work may eventually find application in dendritic cell therapy and vaccination.
Gut Microbiota and Obesity: Pig Model
The microbiota is a complex collaborative ecosystem of microorganisms that live in a pre-established environment. The most accessible form of microbiome in popular culture is that of the human gut, which has been implicated in both immunity and obesity. The "Pig Project" recognizes the extensive similarities between the human and the pig digestive tract and examines how the metagenome and phage content of the microbiome evolves during a progression toward obesity.